Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation

In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism often develops. Donor T cell macrochimerism (≥4%) frequently occurs without graft-versus-host disease (GVHD) and is associated with reduced rejection. Here we demonstrate that patients with macrochimerism ha...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Fu, Jianing, Zuber, Julien, Shonts, Brittany, Obradovic, Aleksandar, Wang, Zicheng, Frangaj, Kristjana, Meng, Wenzhao, Rosenfeld, Aaron M., Waffarn, Elizabeth E., Liou, Peter, Lau, Sai-ping, Savage, Thomas M., Yang, Suxiao, Rogers, Kortney, Danzl, Nichole M., Ravella, Shilpa, Satwani, Prakash, Iuga, Alina, Ho, Siu-hong, Griesemer, Adam, Shen, Yufeng, Prak, Eline T. Luning, Martinez, Mercedes, Kato, Tomoaki, Sykes, Megan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062082/
https://ncbi.nlm.nih.gov/pubmed/33630757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141698
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