Octreotide inhibits secretion of IGF-1 from orbital fibroblasts in patients with thyroid-associated ophthalmopathy via inhibition of the NF-κB pathway

PURPOSE: We investigated the effect of octreotide, a long-acting somatostatin (SST) analogue, on IGF-1 secretion and its possible mechanism of action in orbital fibroblasts (OFs) from patients with thyroid-associated ophthalmopathy (TAO). MATERIALS AND METHODS: OFs were isolated from the orbital fat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kim, Sung Eun, Kim, Jia, Lee, Ji-Young, Lee, Seong-Beom, Paik, Ji-Sun, Yang, Suk-Woo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062018/
https://ncbi.nlm.nih.gov/pubmed/33886620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0249988
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