Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data

IMPORTANCE: Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered brain glutamatergic function may be associated with the pathophysiology of schizophrenia and the response to antipsychotic treatment. However, the association of altered glutamatergic function with clinical and...

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Bibliografiske detaljer
Udgivet i:JAMA Psychiatry
Main Authors: Merritt, Kate, McGuire, Philip K., Egerton, Alice, Aleman, André, Block, Wolfgang, Bloemen, Oswald J. N., Borgan, Faith, Bustillo, Juan R., Capizzano, Aristides A., Coughlin, Jennifer Marie, De la Fuente-Sandoval, Camilo, Demjaha, Arsime, Dempster, Kara, Do, Kim Q., Du, Fei, Falkai, Peter, Galinska-Skok, Beata, Gallinat, Jurgen, Gasparovic, Charles, Ginestet, Cedric E., Goto, Naoki, Graff-Guerrero, Ariel, Ho, Beng Choon, Howes, Oliver D., Jauhar, Sameer, Jeon, Peter, Kato, Tadafumi, Kaufmann, Charles A., Kegeles, Lawrence S., Keshavan, Matcheri, Kim, Sang-Young, Kunugi, Hiroshi, Lauriello, John, Liemburg, Edith Jantine, Mcilwain, Meghan E., Modinos, Gemma, Mouchlianitis, Elias D., Nakamura, Jun, Nenadic, Igor, Öngür, Dost, Ota, Miho, Palaniyappan, Lena, Pantelis, Christos, Plitman, Eric, Posporelis, Sotirios, Purdon, Scot E., Reichenbach, Jürgen R., Renshaw, Perry F., Russell, Bruce R., Sawa, Akira, Schaefer, Martin, Shungu, Dikoma C., Smesny, Stefan, Stanley, Jeffrey A., Stone, James M., Szulc, Agata, Taylor, Reggie, Thakkar, Katy, Théberge, Jean, Tibbo, Philip G., van Amelsvoort, Therese, Walecki, Jerzy, Williamson, Peter C., Wood, Stephen James, Xin, Lijing, Yamasue, Hidenori
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2021
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060889/
https://ncbi.nlm.nih.gov/pubmed/33881460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2021.0380
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