Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer

BACKGROUND: More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), the most important factor for directing anti-estrogenic endocrine therapy (ET). Recently, mutations in ESR1 were identified as acquired mechanisms of resistance to...

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Vydáno v:JNCI Cancer Spectr
Hlavní autoři: Dahlgren, Malin, George, Anthony M, Brueffer, Christian, Gladchuk, Sergii, Chen, Yilun, Vallon-Christersson, Johan, Hegardt, Cecilia, Häkkinen, Jari, Rydén, Lisa, Malmberg, Martin, Larsson, Christer, Gruvberger-Saal, Sofia K, Ehinger, Anna, Loman, Niklas, Borg, Åke, Saal, Lao H
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060794/
https://ncbi.nlm.nih.gov/pubmed/33937624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkab028
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