Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model

Mitochondrial dysfunction underlying metabolic disorders such as obesity and diabetes mellitus is strongly associated with cardiac arrhythmias. Murine Pgc-1α(−/−) hearts replicate disrupted mitochondrial function and model the associated pro-arrhythmic electrophysiological abnormalities. Quantitativ...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab Rep
Main Authors: Saadeh, Khalil, Chadda, Karan R., Ahmad, Shiraz, Valli, Haseeb, Nanthakumar, Nakulan, Fazmin, Ibrahim T., Edling, Charlotte E., Huang, Christopher L.-H., Jeevaratnam, Kamalan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8059080/
https://ncbi.nlm.nih.gov/pubmed/33898262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgmr.2021.100753
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