Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity

Trastuzumab (TZM) is useful in the clinical management of HER2-positive metastatic breast, gastric, and colorectal carcinoma but has been limited by its off-target cardiotoxicity. This study investigates the therapeutic potentials of 0.25 mg/kg/day amlodipine, 0.035 mg/kg/day lisinopril, 5 mg/kg/day...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Olorundare, Olufunke Esan, Adeneye, Adejuwon Adewale, Akinsola, Akinyele Olubiyi, Ajayi, Abayomi Mayowa, Agede, Olalekan Ayodele, Soyemi, Sunday Sokunle, Mgbehoma, Alban Ikenna, Okoye, Ikechukwu Innocent, Albrecht, Ralph M., Ntambi, James Mukasa, Crooks, Peter Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058606/
https://ncbi.nlm.nih.gov/pubmed/33897413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.610331
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