Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab

BACKGROUND: Combined treatment with anthracyclines (e.g., doxorubicin; Dox) and trastuzumab (Trz), a humanized anti-human epidermal growth factor receptor 2 (HER2; ErbB2) antibody, in patients with HER2-positive cancer is limited by cardiotoxicity, as manifested by contractile dysfunction and arrhyt...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Altomare, Claudia, Lodrini, Alessandra Maria, Milano, Giuseppina, Biemmi, Vanessa, Lazzarini, Edoardo, Bolis, Sara, Pernigoni, Nicolò, Torre, Eleonora, Arici, Martina, Ferrandi, Mara, Barile, Lucio, Rocchetti, Marcella, Vassalli, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058443/
https://ncbi.nlm.nih.gov/pubmed/33897465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.658790
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