Are paternal or grandmaternal age associated with higher probability of trisomy 21 in offspring? A population-based, matched case-control study, 1995-2015

BACKGROUND: Fetal aneuploidy risk increases with maternal age, but the majority of pregnancies complicated by trisomy 21 occur in younger women. It has been suggested that grandmaternal and/or paternal age may also play a role. OBJECTIVES: To assess the association between grandmaternal and paternal...

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Bibliographic Details
Published in:Paediatr Perinat Epidemiol
Main Authors: Schliep, Karen C., Feldkamp, Marcia L., Hanson, Heidi A., Hollingshaus, Michael, Fraser, Alison, Smith, Ken R., Panushka, Katherine A., Varner, Michael W.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058293/
https://ncbi.nlm.nih.gov/pubmed/33258505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ppe.12737
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