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Bayesian Markov models improve the prediction of binding motifs beyond first order

Transcription factors (TFs) regulate gene expression by binding to specific DNA motifs. Accurate models for predicting binding affinities are crucial for quantitatively understanding of transcriptional regulation. Motifs are commonly described by position weight matrices, which assume that each posi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:NAR Genom Bioinform
Egile Nagusiak: Ge, Wanwan, Meier, Markus, Roth, Christian, Söding, Johannes
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2021
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057495/
https://ncbi.nlm.nih.gov/pubmed/33928244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nargab/lqab026
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