C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia

BACKGROUND: Excessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and is associated with enhanced pathogenicity and mortality. OBJECTIVE: Complement hyperactivation promotes lung injury and was ob...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Posch, Wilfried, Vosper, Jonathan, Noureen, Asma, Zaderer, Viktoria, Witting, Christina, Bertacchi, Giulia, Gstir, Ronald, Filipek, Przemyslaw A., Bonn, Günther K., Huber, Lukas A., Bellmann-Weiler, Rosa, Lass-Flörl, Cornelia, Wilflingseder, Doris
Formato: Artigo
Idioma:Inglês
Publicado em: The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. 2021
Assuntos:
Covid-19
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056780/
https://ncbi.nlm.nih.gov/pubmed/33852936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2021.03.038
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