STING enhances cell death through regulation of reactive oxygen species and DNA damage

Resistance to DNA-damaging agents is a significant cause of treatment failure and poor outcomes in oncology. To identify unrecognized regulators of cell survival we performed a whole-genome CRISPR-Cas9 screen using treatment with ionizing radiation as a selective pressure, and identified STING (stim...

詳細記述

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書誌詳細
出版年:Nat Commun
主要な著者: Hayman, Thomas J., Baro, Marta, MacNeil, Tyler, Phoomak, Chatchai, Aung, Thazin Nwe, Cui, Wei, Leach, Kevin, Iyer, Radhakrishnan, Challa, Sreerupa, Sandoval-Schaefer, Teresa, Burtness, Barbara A., Rimm, David L., Contessa, Joseph N.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055995/
https://ncbi.nlm.nih.gov/pubmed/33875663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22572-8
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