Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8

Chronic loss of Augmenter of Liver Regeneration (ALR) results in mitochondrial myopathy with cataracts; however, the mechanism for this disorder remains unclear. Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein import pathway, results in impaired cytosolic Fe/S c...

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Pubblicato in:eLife
Autori principali: Chang, Hsiang-Chun, Shapiro, Jason Solomon, Jiang, Xinghang, Senyei, Grant, Sato, Teruki, Geier, Justin, Sawicki, Konrad T, Ardehali, Hossein
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2021
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055271/
https://ncbi.nlm.nih.gov/pubmed/33835027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65158
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