טוען...

Supramolecular assembly of Toll-like receptor 7/8 agonist into multimeric water-soluble constructs enables superior immune stimulation in vitro and in vivo

Resiquimod or R848 (RSQD) is a Toll-like receptor (TLR) 7/8 agonist which shows promise as vaccine adjuvant due to its potential to promote highly desirable cellular immunity. The development of this small molecule in the field to date has been largely impeded by its rapid in vivo clearance and lack...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:ACS Appl Bio Mater
Main Authors: Andrianov, Alexander K., Marin, Alexander, Wang, Ruixue, Karauzum, Hatice, Chowdhury, Ananda, Agnihotri, Pragati, Yunus, Abdul S., Mariuzza, Roy A., Fuerst, Thomas R.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054952/
https://ncbi.nlm.nih.gov/pubmed/33880435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsabm.0c00189
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