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Accumulation of PSA-NCAM marks nascent neurodegeneration in the dorsal hippocampus after neonatal hypoxic-ischemic brain injury in mice

Neonatal hypoxia-ischemia (nHI) disrupts hippocampal GABAergic development leading to memory deficits in mice. Polysialic-acid neural-cell adhesion molecule (PSA-NCAM) developmentally declines to trigger GABAergic maturation. We hypothesized that nHI changes PSA-NCAM abundance and cellular distribut...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Chavez-Valdez, Raul, Lechner, Charles, Emerson, Paul, Northington, Frances J, Martin, Lee J
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054724/
https://ncbi.nlm.nih.gov/pubmed/32703109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X20942707
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