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Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage
Ubiquitination by Nedd4 (neuronally expressed developmentally downregulated 4) family of HECT type E3 ligases plays a key role in degrading misfolded and damaged proteins, and its disruption leads to neurodegeneration. Parkinson's disease-causing protein α-Synuclein (α-Syn) is ubiquitinated by...
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| Publicado no: | J Cereb Blood Flow Metab |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8054722/ https://ncbi.nlm.nih.gov/pubmed/32703111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X20943804 |
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