Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research and antiviral discovery are hampered by the lack of a cell-based virus replication system that can be readily adopted without biosafety level 3 (BSL-3) restrictions. Here, the construction of a noninfectious SARS-CoV-2 reporter re...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: He, Xi, Quan, Shuo, Xu, Min, Rodriguez, Silveria, Goh, Shih Lin, Wei, Jiajie, Fridman, Arthur, Koeplinger, Kenneth A., Carroll, Steve S., Grobler, Jay A., Espeseth, Amy S., Olsen, David B., Hazuda, Daria J., Wang, Dai
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053989/
https://ncbi.nlm.nih.gov/pubmed/33766889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025866118
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