Direct coordination of pterin to Fe(II) enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases

The pterin-dependent nonheme iron enzymes hydroxylate aromatic amino acids to perform the biosynthesis of neurotransmitters to maintain proper brain function. These enzymes activate oxygen using a pterin cofactor and an aromatic amino acid substrate bound to the Fe(II) active site to form a highly r...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Iyer, Shyam R., Tidemand, Kasper D., Babicz, Jeffrey T., Jacobs, Ariel B., Gee, Leland B., Haahr, Lærke T., Yoda, Yoshitaka, Kurokuzu, Masayuki, Kitao, Shinji, Saito, Makina, Seto, Makoto, Christensen, Hans E. M., Peters, Günther H. J., Solomon, Edward I.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Physical Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053929/
https://ncbi.nlm.nih.gov/pubmed/33876764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022379118
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