Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma

Defects in tumor-intrinsic interferon (IFN) signaling result in failure of immune checkpoint blockade (ICB) against cancer, but these tumors may still maintain sensitivity to T cell–based adoptive cell therapy (ACT). We generated models of IFN signaling defects in B16 murine melanoma observed in pat...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Kalbasi, Anusha, Tariveranmoshabad, Mito, Hakimi, Kevin, Kremer, Sarah, Campbell, Katie M., Funes, Juan M., Vega-Crespo, Agustin, Parisi, Giulia, Champekar, Ameya, Nguyen, Christine, Torrejon, Davis, Shin, Daniel, Zaretsky, Jesse M., Damoiseaux, Robert D., Speiser, Daniel E., Lopez-Casas, Pedro P., Quintero, Marisol, Ribas, Antoni
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053376/
https://ncbi.nlm.nih.gov/pubmed/33055240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abb0152
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