IL-6 Regulates Hepcidin Expression Via the BMP/SMAD Pathway by Altering BMP6, TMPRSS6 and TfR2 Expressions at Normal and Inflammatory Conditions in BV2 Microglia

The hormone hepcidin plays a central role in controlling iron homeostasis. Iron-mediated hepcidin synthesis is triggered via the BMP/SMAD pathway. At inflammation, mainly IL-6 pro-inflammatory cytokine mediates the regulation of hepcidin via the JAK/STAT signalling pathway. Microglial cells of the c...

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Publicado en:Neurochem Res
Autores principales: Varga, Edit, Pap, Ramóna, Jánosa, Gergely, Sipos, Katalin, Pandur, Edina
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2021
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053173/
https://ncbi.nlm.nih.gov/pubmed/33835366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-021-03322-0
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