Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition

Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity. Here, we report crystal structures of Thermus oshim...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Dai, Yang-Xue, Chen, Wei-Fei, Liu, Na-Nv, Teng, Fang-Yuan, Guo, Hai-Lei, Hou, Xi-Miao, Dou, Shuo-Xing, Rety, Stephane, Xi, Xu-Guang
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2021
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053095/
https://ncbi.nlm.nih.gov/pubmed/33784404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab188
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