Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition

Pif1 is an SF1B helicase that is evolutionarily conserved from bacteria to humans and plays multiple roles in maintaining genome stability in both nucleus and mitochondria. Though highly conserved, Pif1 family harbors a large mechanistic diversity. Here, we report crystal structures of Thermus oshim...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Dai, Yang-Xue, Chen, Wei-Fei, Liu, Na-Nv, Teng, Fang-Yuan, Guo, Hai-Lei, Hou, Xi-Miao, Dou, Shuo-Xing, Rety, Stephane, Xi, Xu-Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053095/
https://ncbi.nlm.nih.gov/pubmed/33784404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab188
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