Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection

Somatic expansion of the CAG repeat tract that causes Huntington's disease (HD) is thought to contribute to the rate of disease pathogenesis. Therefore, factors influencing repeat expansion are potential therapeutic targets. Genes in the DNA mismatch repair pathway are critical drivers of somat...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Roy, Jennie C L, Vitalo, Antonia, Andrew, Marissa A, Mota-Silva, Eduarda, Kovalenko, Marina, Burch, Zoe, Nhu, Anh M, Cohen, Paula E, Grabczyk, Ed, Wheeler, Vanessa C, Mouro Pinto, Ricardo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2021
Ämnen:
Genome Integrity, Repair and Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053082/
https://ncbi.nlm.nih.gov/pubmed/33751106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab152
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk