TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9). Additionally, mycobacteria harbor immuno-evasive cell-wall lipids associated with virulence and late...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Iizasa, Ei’ichi, Chuma, Yasushi, Uematsu, Takayuki, Kubota, Mio, Kawaguchi, Hiroaki, Umemura, Masayuki, Toyonaga, Kenji, Kiyohara, Hideyasu, Yano, Ikuya, Colonna, Marco, Sugita, Masahiko, Matsuzaki, Goro, Yamasaki, Sho, Yoshida, Hiroki, Hara, Hiromitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052348/
https://ncbi.nlm.nih.gov/pubmed/33863908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22620-3
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