Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis

Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical and functional associations with sensory afferent neurons. We reveal that epidermal nerve endings from a subset of sensory nonpeptidergic neurons expressing MrgprD are reduced by the absence of Langerhans cells. Lo...

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Publicado en:Cell
Main Authors: Zhang, Shiqun, Edwards, Tara N., Chaudhri, Virendra K., Wu, Jianing, Cohen, Jonathan A., Hirai, Toshiro, Rittenhouse, Natalie, Schmitz, Elizabeth G., Zhou, Paul Yifan, McNeil, Benjamin D., Yang, Yi, Koerber, H. Richard, Sumpter, Tina L., Poholek, Amanda C., Davis, Brian M., Albers, Kathryn M., Singh, Harinder, Kaplan, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052305/
https://ncbi.nlm.nih.gov/pubmed/33765440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.03.002
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