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Knockout of γ-Adducin Promotes N(G)-Nitro-L-Arginine-Methyl-Ester–Induced Hypertensive Renal Injury
Previous studies identified a region on chromosome 1 associated with N(G)-nitro-L-arginine methyl ester (L-NAME) hypertension-induced renal disease in fawn-hooded hypertensive (FHH) rats. This region contains a mutant γ-adducin (Add3) gene that impairs renal blood flow (RBF) autoregulation, but its...
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| Veröffentlicht in: | J Pharmacol Exp Ther |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8051517/ https://ncbi.nlm.nih.gov/pubmed/33414130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000408 |
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