The ligand-bound state of a G protein-coupled receptor stabilizes the interaction of functional cholesterol molecules

Cholesterol is a major component of mammalian plasma membranes that not only affects the physical properties of the lipid bilayer but also is the function of many membrane proteins including G protein-coupled receptors. The oxytocin receptor (OXTR) is involved in parturition and lactation of mammals...

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Vydáno v:J Lipid Res
Hlavní autoři: Lemel, Laura, Nieścierowicz, Katarzyna, García-Fernández, M. Dolores, Darré, Leonardo, Durroux, Thierry, Busnelli, Marta, Pezet, Mylène, Rébeillé, Fabrice, Jouhet, Juliette, Mouillac, Bernard, Domene, Carmen, Chini, Bice, Cherezov, Vadim, Moreau, Christophe J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050779/
https://ncbi.nlm.nih.gov/pubmed/33647276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jlr.2021.100059
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