Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids

Intestinal epithelial cells (IEC) reside in close proximity to the gut microbiota and are hypo-responsive to bacterial products, likely to prevent maladaptive inflammatory responses. This is in part due to their strong expression of Single Ig IL-1 related receptor (SIGIRR), a negative regulator of i...

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Pubblicato in:Sci Rep
Autori principali: Allaire, Joannie M., Poon, Anita, Crowley, Shauna M., Han, Xiao, Sharafian, Zohreh, Moore, Navjit, Stahl, Martin, Bressler, Brian, Lavoie, Pascal M., Jacobson, Kevan, Li, Xiaoxia, Vallance, Bruce A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050237/
https://ncbi.nlm.nih.gov/pubmed/33859245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87592-2
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