First-in-Humans Study of (68)Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1

Sialic acid–binding immunoglubulinlike lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1. A (68)Ga-labeled peptide of Siglec-9, (68)Ga-DOTA-Siglec-9, holds promise as a novel PET tracer for imaging of inflammation. This first-in-humans study investigated the safety, tolerability, biodis...

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Publicat a:J Nucl Med
Autors principals: Viitanen, Riikka, Moisio, Olli, Lankinen, Petteri, Li, Xiang-Guo, Koivumäki, Mikko, Suilamo, Sami, Tolvanen, Tuula, Taimen, Kirsi, Mali, Markku, Kohonen, Ia, Koskivirta, Ilpo, Oikonen, Vesa, Virtanen, Helena, Santalahti, Kristiina, Autio, Anu, Saraste, Antti, Pirilä, Laura, Nuutila, Pirjo, Knuuti, Juhani, Jalkanen, Sirpa, Roivainen, Anne
Format: Artigo
Idioma:Inglês
Publicat: Society of Nuclear Medicine 2021
Matèries:
Inflammation/Infection
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049366/
https://ncbi.nlm.nih.gov/pubmed/32817143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.120.250696
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