Pharmacokinetics and Drug‐Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping

The World Health Organization guidelines recommend that individuals living with HIV receive ≥ 6 months of isoniazid preventive therapy, including pregnant women. Yet, plasma isoniazid exposure during pregnancy, in the antiretroviral therapy era, has not been well‐described. We investigated pregnancy...

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Publicado en:Clin Pharmacol Ther
Autores principales: Gausi, Kamunkhwala, Wiesner, Lubbe, Norman, Jennifer, Wallis, Carole L., Onyango‐Makumbi, Carolyne, Chipato, Tsungai, Haas, David W., Browning, Renee, Chakhtoura, Nahida, Montepiedra, Grace, Aaron, Lisa, McCarthy, Katie, Bradford, Sarah, Vhembo, Tichaona, Stranix‐Chibanda, Lynda, Masheto, Gaerolwe R., Violari, Avy, Mmbaga, Blandina T., Aurpibul, Linda, Bhosale, Ramesh, Nevrekhar, Neetal, Rouzier, Vanessa, Kabugho, Enid, Mutambanengwe, Mercy, Chanaiwa, Vongai, Nyati, Mandisa, Mhembere, Tsungai, Tongprasert, Fuanglada, Hesseling, Anneke, Shin, Katherine, Zimmer, Bonnie, Costello, Diane, Jean‐Philippe, Patrick, Sterling, Timothy R., Theron, Gerhard, Weinberg, Adriana, Gupta, Amita, Denti, Paolo
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048881/
https://ncbi.nlm.nih.gov/pubmed/32909316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2044
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