Humanized anti-DEspR IgG4(S228P) antibody increases overall survival in a pancreatic cancer stem cell-xenograft peritoneal carcinomatosis rat(nu/nu) model

BACKGROUND: Pancreatic peritoneal carcinomatosis (PPC), with the worst median overall-survival (mOS), epitomizes the incurability of metastatic cancer. Cancer stem cells (CSCs) underpin this incurability. However, inhibitors of CSC-stemness fail to increase mOS in cancer patients despite preclinical...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Gromisch, Christopher M., Tan, Glaiza L. A., Pasion, Khristine Amber, Moran, Ann-Marie, Gromisch, Matthew S., Grinstaff, Mark W., Carr, Francis J., Herrera, Victoria L. M., Ruiz-Opazo, Nelson
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048286/
https://ncbi.nlm.nih.gov/pubmed/33853558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-08107-w
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