Exaggerated BMP4 Signaling Alters Human Airway Basal Progenitor Cell Differentiation to Cigarette Smoking-related Phenotypes

Airway remodeling in chronic obstructive pulmonary disease (COPD) originates, in part, from smoking-induced changes in airway basal stem/progenitor cells (BC). Based on the knowledge that the bone morphogenetic protein 4 (BMP4) influences epithelial progenitor function in the developing and adult mo...

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Bibliographic Details
Published in:Eur Respir J
Main Authors: Zuo, Wu-Lin, Yang, Jing, Strulovici-Barel, Yael, Salit, Jacqueline, Rostami, Mahboubeh, Mezey, Jason G., O’Beirne, Sarah L., Kaner, Robert J., Crystal, Ronald G.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8048147/
https://ncbi.nlm.nih.gov/pubmed/30705127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02553-2017
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