Establishing RNA-RNA interactions remodels lncRNA structure and promotes PRC2 activity

Human Polycomb Repressive Complex 2 (PRC2) catalysis of histone H3 lysine 27 methylation at certain loci depends on long noncoding RNAs (lncRNAs). Yet, in apparent contradiction, RNA is a potent catalytic inhibitor of PRC2. Here, we show that intermolecular RNA-RNA interactions between the lncRNA HO...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Balas, Maggie M., Hartwick, Erik W., Barrington, Chloe, Roberts, Justin T., Wu, Stephen K., Bettcher, Ryan, Griffin, April M., Kieft, Jeffrey S., Johnson, Aaron M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8046370/
https://ncbi.nlm.nih.gov/pubmed/33853770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc9191
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados