Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?

The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated. We appraise the nature of the interplay between Abacavir and P2X7R in generating vas...

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Publicado en:Front Pharmacol
Autores principales: Collado-Díaz, Víctor, Martinez-Cuesta, Maria Ángeles, Blanch-Ruiz, Maria Amparo, Sánchez-López, Ainhoa, García-Martínez, Patricia, Peris, José E, Usach, Iris, Ivorra, Maria Dolores, Lacetera, Alessandra, Martín-Santamaría, Sonsoles, Esplugues, Juan V., Alvarez, Angeles
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045785/
https://ncbi.nlm.nih.gov/pubmed/33867979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.613449
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