Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

Cell-based therapies are emerging as effective agents against cancer and other diseases. As autonomous “living drugs,” these therapies lack precise control. Chimeric antigen receptor (CAR) T cells effectively target hematologic malignancies but can proliferate rapidly and cause toxicity. We develope...

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Publicado no:Sci Transl Med
Main Authors: Jan, Max, Scarfò, Irene, Larson, Rebecca C, Walker, Amanda, Schmidts, Andrea, Guirguis, Andrew A, Gasser, Jessica A, Słabicki, Mikołaj, Bouffard, Amanda A, Castano, Ana P, Kann, Michael C, Cabral, Maria L, Tepper, Alexander, Grinshpun, Daniel E, Sperling, Adam S, Kyung, Taeyoon, Sievers, Quinlan, Birnbaum, Michael E, Maus, Marcela V, Ebert, Benjamin L
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045771/
https://ncbi.nlm.nih.gov/pubmed/33408186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abb6295
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