Concurrent use of metformin enhances the efficacy of EGFR-TKIs in patients with advanced EGFR-mutant non-small cell lung cancer—an option for overcoming EGFR-TKI resistance

BACKGROUND: Resistance is almost inevitable and is still a major obstacle in epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy. Only limited relevant clinical studies evaluated the therapeutic effects by combing metformin and EGFR-TKIs in non-small cell lung cancer (NSC...

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Detalhes bibliográficos
Publicado no:Transl Lung Cancer Res
Main Authors: Han, Ruoshuang, Jia, Yijun, Li, Xuefei, Zhao, Chao, Zhao, Sha, Liu, Sangtian, Liu, Yiwei, Chen, Donglai, Zhang, Qian, Liu, Xiaozhen, Shi, Jinpeng, Li, Jiayu, Zhou, Caicun
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044488/
https://ncbi.nlm.nih.gov/pubmed/33889509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tlcr-20-1153
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