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Panels and models for accurate prediction of tumor mutation burden in tumor samples

Immune checkpoint blockade (ICB) is becoming standard-of-care in many types of human malignancies, but patient selection is still imperfect. Tumor mutation burden (TMB) is being evaluated as a biomarker for ICB in clinical trials, but most of the sequencing panels used to estimate it are inadequatel...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:NPJ Precis Oncol
Hauptverfasser: Martínez-Pérez, Elizabeth, Molina-Vila, Miguel Angel, Marino-Buslje, Cristina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044185/
https://ncbi.nlm.nih.gov/pubmed/33850256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-021-00169-0
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