LC-MS/MS method for simultaneous quantification of dexamethasone and tobramycin in rabbit ocular biofluids

The complexity of Tobradex® ointment formulation (dexamethasone 0.1 wt% and tobramycin 0.3 wt%) and the high cost of pharmacokinetic (PK) studies in human aqueous humor prevent generic drug companies from moving forward with a Tobradex®-equivalent product development. The in vitro drug release test...

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Detalhes bibliográficos
Publicado no:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Meng, Tuo, Kosmider, Leon, Chai, Guihong, Raynold, Aji Alex Moothedathu, Pearcy, Adam, Qin, Bin, Wang, Yan, Lu, Xiuling, Halquist, Matthew S., Xu, Qingguo
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044036/
https://ncbi.nlm.nih.gov/pubmed/33713949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2021.122610
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