Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature

Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellular parasites. Consistent with this, transcriptional a...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Farias Amorim, Camila, O. Novais, Fernanda, Nguyen, Ba T., Nascimento, Mauricio T., Lago, Jamile, Lago, Alexsandro S., Carvalho, Lucas P., Beiting, Daniel P., Scott, Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043375/
https://ncbi.nlm.nih.gov/pubmed/33793565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0009321
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