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Poison exons in neurodevelopment and disease

Poison exons are naturally occurring, highly conserved alternative exons that contain a premature termination codon. Inclusion of a poison exon in a transcript targets the transcript for nonsense mediated decay, decreasing the amount of protein produced. Poison exons are proposed to play an importan...

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Detalles Bibliográficos
Publicado en:Curr Opin Genet Dev
Autores principales: Carvill, Gemma L, Mefford, Heather C
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042789/
https://ncbi.nlm.nih.gov/pubmed/32615329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2020.05.030
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