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Petasin and isopetasin reduce CGRP release from trigeminal afferents indicating an inhibitory effect on TRPA1 and TRPV1 receptor channels

BACKGROUND: Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. Calcitonin gene-related peptide (CGRP) is known as a biomarker and promoting factor of migraine...

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Detalhes bibliográficos
Publicado no:J Headache Pain
Main Authors: Kleeberg-Hartmann, Johanna, Vogler, Birgit, Messlinger, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Milan 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042690/
https://ncbi.nlm.nih.gov/pubmed/33849430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10194-021-01235-5
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