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Petasin and isopetasin reduce CGRP release from trigeminal afferents indicating an inhibitory effect on TRPA1 and TRPV1 receptor channels
BACKGROUND: Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. Calcitonin gene-related peptide (CGRP) is known as a biomarker and promoting factor of migraine...
Enregistré dans:
| Publié dans: | J Headache Pain |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer Milan
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8042690/ https://ncbi.nlm.nih.gov/pubmed/33849430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10194-021-01235-5 |
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