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Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression
Mitotic entry involves inhibition of protein phosphatase 2A bound to its B55/Tws regulatory subunit (PP2A-B55/Tws), which dephosphorylates substrates of mitotic kinases. This inhibition is induced when Greatwall phosphorylates Endos, turning it into an inhibitor of PP2A-Tws. How this mechanism opera...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8042607/ https://ncbi.nlm.nih.gov/pubmed/33836042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202008145 |
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