Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model

Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a small subset of patients, partly because of the lack of sufficient immune cells in the tumor. It is reported that targeted lactate dehydrogenase (LDH) to reduce lactic acid production can promote the infilt...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Qiao, Tianyun, Xiong, Yanlu, Feng, Yangbo, Guo, Wenwen, Zhou, Yongsheng, Zhao, Jinbo, Jiang, Tao, Shi, Changhong, Han, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042335/
https://ncbi.nlm.nih.gov/pubmed/33859941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.632364
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