Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer

γδ T cells are a distinct subgroup of T cells that bridge the innate and adaptive immune system and can attack cancer cells in an MHC-unrestricted manner. Trials of adoptive γδ T cell transfer in solid tumors have had limited success. Here, we show that DNA methyltransferase inhibitors (DNMTis) upre...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Weng, Rueyhung R., Lu, Hsuan-Hsuan, Lin, Chien-Ting, Fan, Chia-Chi, Lin, Rong-Shan, Huang, Tai-Chung, Lin, Shu-Yung, Huang, Yi-Jhen, Juan, Yi-Hsiu, Wu, Yi-Chieh, Hung, Zheng-Ci, Liu, Chi, Lin, Xuan-Hui, Hsieh, Wan-Chen, Chiu, Tzu-Yuan, Liao, Jung-Chi, Chiu, Yen-Ling, Chen, Shih-Yu, Yu, Chong-Jen, Tsai, Hsing-Chen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042060/
https://ncbi.nlm.nih.gov/pubmed/33846331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22433-4
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