Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans

Omecamtiv mecarbil (OM) is a promising novel drug for improving cardiac contractility. We tested the therapeutic range of OM and identified previously unrecognized side effects. The Ca(2+) sensitivity of isometric force production (pCa(50)) and force at low Ca(2+) levels increased with OM concentrat...

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Publicado no:Basic Res Cardiol
Main Authors: Fülöp, Gábor Á., Oláh, Attila, Csipo, Tamas, Kovács, Árpád, Pórszász, Róbert, Veress, Roland, Horváth, Balázs, Nagy, László, Bódi, Beáta, Fagyas, Miklós, Helgadottir, Solveig Lind, Bánhegyi, Viktor, Juhász, Béla, Bombicz, Mariann, Priksz, Daniel, Nanasi, Peter, Merkely, Béla, Édes, István, Csanádi, Zoltán, Papp, Zoltán, Radovits, Tamás, Tóth, Attila
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
Assuntos:
Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041714/
https://ncbi.nlm.nih.gov/pubmed/33844095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-021-00866-8
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