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Fast and Stable N-Terminal Cysteine Modification via Thiazolidino Boronate Mediated Acyl Transfer
We report herein a novel conjugation chemistry of N-terminal cysteines (NCys) that proceeds with fast kinetics and exquisite selectivity, allowing facile modification of NCys-bearing proteins in complex biological milieu. This new NCys conjugation proceeds with a thiazolidine boronate (TzB) intermed...
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| Publicat a: | Angew Chem Int Ed Engl |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8041485/ https://ncbi.nlm.nih.gov/pubmed/32437040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202000837 |
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