Classical complement and inflammasome activation converge in CD14(high)CD16(-) monocytes in HIV associated TB-immune reconstitution inflammatory syndrome

Inflammasome-derived cytokines, IL-1β and IL-18, and complement cascade have been independently implicated in the pathogenesis of tuberculosis (TB)-immune reconstitution inflammatory syndrome (TB-IRIS), a complication affecting HIV(+) individuals starting antiretroviral therapy (ART). Although subly...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Lage, Silvia Lucena, Wong, Chun-Shu, Amaral, Eduardo Pinheiro, Sturdevant, Daniel, Hsu, Denise C., Rupert, Adam, Wilson, Eleanor M. P., Qasba, S. Sonia, Naqvi, Nuha Sultana, Laidlaw, Elizabeth, Lisco, Andrea, Manion, Maura, Sereti, Irini
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041190/
https://ncbi.nlm.nih.gov/pubmed/33788899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009435
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