Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination

Chronic inflammation is thought to be a major cause of morbidity and mortality in aging, but whether similar mechanisms underlie dysfunction in infection-associated chronic inflammation is unclear. Here, we profiled the immune proteome, and cellular composition and signaling states in a cohort of ag...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Lopez Angel, Cesar J., Pham, Edward A., Du, Huixun, Vallania, Francesco, Fram, Benjamin J., Perez, Kevin, Nguyen, Thai, Rosenberg-Hasson, Yael, Ahmed, Aijaz, Dekker, Cornelia L., Grant, Philip M., Khatri, Purvesh, Maecker, Holden T., Glenn, Jeffrey S., Davis, Mark M., Furman, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040665/
https://ncbi.nlm.nih.gov/pubmed/33811141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022928118
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