Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling

Implant-derived wear particles can be phagocytosed by local macrophages, triggering an inflammatory cascade that can drive the activation and recruitment of osteoclasts, thereby inducing peri-prosthetic osteolysis. Efforts to suppress pro-inflammatory cytokine release and osteoclastsogenesis thus re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Biol Sci
Prif Awduron: Li, Ning, Li, Xiaoping, Zheng, Kai, Bai, Jiaxiang, Zhang, Weicheng, Sun, Houyi, Ge, Gaoran, Wang, Wei, Wang, Zhen, Gu, Ye, Xue, Yi, Xu, Yaozeng, Geng, Dechun, Zhou, Jun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Ivyspring International Publisher 2021
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040473/
https://ncbi.nlm.nih.gov/pubmed/33867853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.53992
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