Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation

Hypoxic microenvironment is a hallmark of solid tumors, especially glioblastoma. The strong reliance of glioma-propagating cells (GPCs) on hypoxia-induced survival advantages is potentially exploitable for drug development. Methods: To identify key signaling pathways for hypoxia adaptation by patien...

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Cheng, Hong Sheng, Marvalim, Charlie, Zhu, Pengcheng, Law, Cheng Lui Daniel, Low, Zhi Yan Jeremy, Chong, Yuk Kien, Ang, Beng Ti, Tang, Carol, Tan, Nguan Soon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039937/
https://ncbi.nlm.nih.gov/pubmed/33859738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.54741
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