Neurometabolite mapping highlights elevated myo-inositol profiles within the developing brain in down syndrome

The neurodevelopmental phenotype in Down Syndrome (DS), or Trisomy 21, is variable including a wide spectrum of cognitive impairment and a high risk of early-onset Alzheimer's disease (AD). A key metabolite of interest within the brain in DS is Myo-inositol (mIns). The NA+/mIns co-transporter i...

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Vydáno v:Neurobiol Dis
Hlavní autoři: Patkee, Prachi A., Baburamani, Ana A., Long, Katherine R., Dimitrova, Ralica, Ciarrusta, Judit, Allsop, Joanna, Hughes, Emer, Kangas, Johanna, McAlonan, Grainne M., Rutherford, Mary A., De Vita, Enrico
Médium: Artigo
Jazyk:Inglês
Vydáno: Academic Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039898/
https://ncbi.nlm.nih.gov/pubmed/33711492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2021.105316
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