Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells

Diminished regeneration or healing capacity of tendon occurs during aging. It has been well demonstrated that tendon stem/progenitor cells (TSPCs) play a vital role in tendon maintenance and repair. Here, we identified an accumulation of senescent TSPCs in tendon tissue with aging. In aged TSPCs, th...

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Udgivet i:Front Cell Dev Biol
Main Authors: Chen, Minhao, Xiao, Longfei, Dai, Guangchun, Lu, Panpan, Zhang, Yuanwei, Li, Yingjuan, Ni, Ming, Rui, Yunfeng
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039155/
https://ncbi.nlm.nih.gov/pubmed/33855026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.650250
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